JOHN'S WORT

The name Hypericum is derived from the two Greek words, huper eikon, "over an apparition," because of its supposed power to exorcise evil spirits, or influences; whence it was also formerly called Fuga doemoniorum, "the Devil's Scourge," "the Grace of God," "the Lord God's Wonder Plant." and some other names of a like import, probably too, because found to be of curative use against insanity. Again, it used to be entitled Hexenkraut, and "Witch's Herb," on account of its reputed magical powers. Matthiolus said, Scripsere quidam Hypericum adeo odisse doemones, ut ejus suffitu statim avolent, "Certain writers have said that the St. John's Wort is so detested by evil spirits that they fly off at a whiff of its odour."

HERBAL SIMPLES APPROVED FOR MODERN USES OF CURE by W. T. FERNIE, M.D. - 1897

What the Science Says
About St. John's Wort for Depression

Scientific evidence regarding the effectiveness of St. John's wort for depression is inconsistent. An analysis of the results of 37 clinical trials concluded that St. John's wort may have only minimal beneficial effects on major depression. However, the analysis also found that St. John's wort may benefit people with minor depression; these benefits may be similar to those from standard antidepressants. Overall, St. John's wort appeared to produce fewer side effects than some standard antidepressants.

One of the studies included in the analysis was cofunded by NCCAM and two other components of the National Institutes of Health (NIH)—the National Institute of Mental Health and the Office of Dietary Supplements. This study found that St. John's wort was no more effective than placebo in treating major depression of moderate severity. However, the antidepressant sertraline, used in one arm of the study, also showed little difference from placebo.