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| ... "The extract of bitter orange (and bitter orange peel) has been marketed as dietary supplement purported to act as a weight-loss aid and appetite suppressant. Bitter orange contains the tyramine metabolites N-methyltyramine, octopamine and synephrine, substances similar to epinephrine, which act on the a1 adrenergic receptor to constrict blood vessels and increase blood pressure and heart rate. There is no evidence that bitter orange is effective in promoting weight loss". |
